Synthesis and Preliminary Biological Evaluation of 99mTc Tricarbonyl Ropinirole as a Potential Brain Imaging Agent
| العنوان: | Synthesis and Preliminary Biological Evaluation of 99mTc Tricarbonyl Ropinirole as a Potential Brain Imaging Agent |
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| المؤلفون: | M. H. Sanad, F. A. Rizvi, R. R. Kumar, A. A. Ibrahim |
| المصدر: | Radiochemistry. 61:754-758 |
| بيانات النشر: | Pleiades Publishing Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Biodistribution, Ropinirole, Chemistry, In vivo, Radiosynthesis, medicine, Physical and Theoretical Chemistry, Combinatorial chemistry, Dopamine agonist, Biological evaluation, medicine.drug |
| الوصف: | Ropinirole, a non-ergoline dopamine agonist, was labeled with 99mTc tricarbonyl {[99mTc(CO)3·(H2O)3]+} with the aim of obtaining a new brain imaging agent. For in vivo use, the radiosynthesis of 99mTc tricarbonyl ropinirole was performed by heating a solution containing ropinirole and the precursor, 99mTc tricarbonyl, on a boiling water bath for 30 min. The influence of the substrate amount and pH on the reaction was studied to optimize the synthesis. The biodistribution and scintigraphic studies demonstrate the suitability of 99mTc tricarbonyl ropinirole as a novel tracer for brain tumor imaging. |
| تدمد: | 1608-3288 1066-3622 |
| DOI: | 10.1134/s1066362219060195 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::289f8d7ae30189461d7ee1f7e2ac55a7 https://doi.org/10.1134/s1066362219060195 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........289f8d7ae30189461d7ee1f7e2ac55a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16083288 10663622 |
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| DOI: | 10.1134/s1066362219060195 |