Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest,1
| العنوان: | Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest,1 |
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| المؤلفون: | Rabodo Andriantsiferana, James S. Miller, Andrew Norris, Jeremi Razafitsalama, Brent J. Yoder, Fidy Ratovoson, Vincent E. Rasamison, Shugeng Cao, David G. I. Kingston |
| المصدر: | Journal of Natural Products. 70:342-346 |
| بيانات النشر: | American Chemical Society (ACS), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Flavonoid, Euphorbiaceae, Pharmaceutical Science, Biological activity, Rainforest, Biology, Pharmacognosy, biology.organism_classification, Terpenoid, Analytical Chemistry, Complementary and alternative medicine, Prenylation, chemistry, Drug Discovery, Molecular Medicine, Macaranga |
| الوصف: | Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E−H (1−4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC50 = 0.13 μM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 μM) was the most potent of the new compounds. |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np060484y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::24c741ca3798d5b15194ab3df0027491 https://doi.org/10.1021/np060484y |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........24c741ca3798d5b15194ab3df0027491 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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| DOI: | 10.1021/np060484y |