Clinical and biochemical effects of propofol EDTA vs sevoflurane in healthy infants and young children1
| العنوان: | Clinical and biochemical effects of propofol EDTA vs sevoflurane in healthy infants and young children1 |
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| المؤلفون: | Ira Todd Cohen, Julia C. Finkel, Raafat S. Hannallah, Goodale David Buell |
| المصدر: | Pediatric Anesthesia. 14:135-142 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Calcium metabolism, business.industry, Hemodynamics, Sevoflurane, Anesthesiology and Pain Medicine, Blood pressure, Anesthesia, Pediatrics, Perinatology and Child Health, Heart rate, medicine, Vomiting, Analysis of variance, medicine.symptom, Propofol, business, medicine.drug |
| الوصف: | Summary Background : Propofol is frequently used for the induction and maintenance of anaesthesia in children aged 3 years and older. The present study compared the clinical and chemical effects of propofol containing disodium edetate (Diprivan®) with that of sevoflurane in children younger than 3 years of age. Methods : This was an open-label, comparative, parallel-group study. Fifty-six healthy children were randomly assigned to receive either propofol (n = 28; mean age 14.7 months) or sevoflurane (n = 28; mean age 13.2 months) for ambulatory surgical procedures. Anaesthesia was induced with nitrous oxide (60%), oxygen and sevoflurane (8%). In the propofol group, it was followed by an intravenous infusion of propofol at a rate of 200 μg·kg−1·min−1. For the sevoflurane group, anaesthesia was maintained with sevoflurane (1.5–2.5%). Haemodynamic measurements, recovery time and side-effects were recorded. Ionized calcium and magnesium concentrations in blood were measured. Statistical analysis was performed using ancova and the Fisher's exact test. Results : The effects of propofol were similar to those of sevoflurane with respect to haemodynamic profile, recovery times (20 min vs 19.4 min) and side-effects (i.e. vomiting 10.7% vs 7.1%). Throughout the study, there were no significant differences between the mean ionized calcium and ionized magnesium concentrations in the two groups. Conclusions : In children younger than 3 years of age, propofol containing ethylenediaminetetraacetic acid has a similar profile to sevoflurane with respect to haemodynamic effects, recovery times, side-effects, ionized calcium and ionized magnesium levels. |
| تدمد: | 1460-9592 1155-5645 |
| DOI: | 10.1111/j.1460-9592.2004.01160.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::244865afb32d3b828086545df5552bc1 https://doi.org/10.1111/j.1460-9592.2004.01160.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........244865afb32d3b828086545df5552bc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14609592 11555645 |
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| DOI: | 10.1111/j.1460-9592.2004.01160.x |