Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype
| العنوان: | Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype |
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| المؤلفون: | Angela Nietz, Clarke Sauve, Haruna Gutierrez, Chris Krook-Magnuson, Zoé Christenson Wick, Esther Krook-Magnuson, Julia Klein, Isaac Hoff |
| المصدر: | Journal of Neurophysiology. 124:1183-1197 |
| بيانات النشر: | American Physiological Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cerebellum, medicine.anatomical_structure, nervous system, Essential tremor, Physiology, General Neuroscience, Protein subunit, medicine, Biology, medicine.disease, Phenotype, nervous system diseases, Cell biology |
| الوصف: | Animals with a global knockout of the GABAAα1 subunit show a tremor phenotype reminiscent of essential tremor. Here we show that selective knockout of GABAAα1 from Purkinje cells is sufficient to produce a tremor phenotype, although this tremor is less severe than seen in animals with a global knockout. These findings illustrate that the cerebellum can play a key role in the genesis of the observed tremor phenotype. |
| تدمد: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00100.2020 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::221d6a691a1fd7ca29c9bafe666129bc https://doi.org/10.1152/jn.00100.2020 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........221d6a691a1fd7ca29c9bafe666129bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221598 00223077 |
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| DOI: | 10.1152/jn.00100.2020 |