JAK3 mediatesc-myc gene expression induced by interleukin-2
| العنوان: | JAK3 mediatesc-myc gene expression induced by interleukin-2 |
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| المؤلفون: | Liu Xinyuan, J. Thèze, Ji Hongbin, Zheng Zhongcheng, Zhu Jinfang, Lu Linrong |
| المصدر: | Chinese Science Bulletin. 43:308-311 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Multidisciplinary, Gene expression, Extracellular, Chimeric gene, Transfection, Signal transduction, Biology, Molecular biology, Gene, Intracellular, Transmembrane protein |
| الوصف: | C-myc gene expression can be rapidly induced by IL-2 through intracellular signal tranduction which is triggered by the interaction between IL-2 and its rccrptor (IL-2R). JAK3 which associates to the intracellular domain of IL-2R γ may play a critical role in this process. To reveal the action of JAK3 in c-nyc induction, a chimeric receptor gene IL-2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL-2K α subunit (IL-2R α), the transmembrane sequence derived from IL-2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 (Δ NJAK3). and then transfected this chimeric gene into nlou. fibroblast cell line L929 β which had been transfected with IL-2R β gene and stably expres.sed IL-2R β in high level. In the transfectants coexpressing IL-2R β and α/γ/Δ NJAK3, the stimulation of IL-2 could intensively induce c-myc gene expression. Because the wholc cytoplasmic domain of IL-2R γ which muld recruit signnling molecules was replaced by JAK3 and thec-myc could be still induced by IL-2 in this situation, the results herc gave the direct evidence demonstrating that JAK3 plays an important role in c-myc gene expression induced by IL-2. |
| تدمد: | 1861-9541 1001-6538 |
| DOI: | 10.1007/bf02884544 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::21f2a4fd3820d642e801ae5a7c50e402 https://doi.org/10.1007/bf02884544 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........21f2a4fd3820d642e801ae5a7c50e402 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18619541 10016538 |
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| DOI: | 10.1007/bf02884544 |