Resveratrol and curcumin: effects on human T cells (50.7)
| العنوان: | Resveratrol and curcumin: effects on human T cells (50.7) |
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| المؤلفون: | Hector Valenzuela, Brenda Molgora, Riley Bateman, Jennifer Wu, Greg Sweeney, Rita Effros |
| المصدر: | The Journal of Immunology. 186:50.7-50.7 |
| بيانات النشر: | The American Association of Immunologists, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Various natural products have been proposed to both increase health at the organismic level, and delay the onset of cellular aging. Of particular interest is resveratrol, a phytoalexin that has been demonstrated to have cardioprotective effects and to slow the progression of a variety of illnesses, including various types of cancers. More recently, resveratrol has been demonstrated to increase the maximum lifespan of model organisms, such as C. elegans, D. melanogaster and N. furzeri. However, the potential health benefits of resveratrol and other similar compounds on the human immune response have not been adequately addressed. We have, therefore, initiated research to determine the in vitro effects of the nutraceuticals resveratrol, and its analogs (polydatin and acetyl-resveratrol), as well as curcumin on a variety of human T cell functions. In this study we evaluated the effect of these compounds on proliferative potential, telomerase activity, expression of costimulatory and memory surface markers and sirtuin gene expression profiles of both human CD4 and CD8 T cells. Our data show that these compounds stimulated strong dose-dependent anti-inflammatory responses, and upregulated surface protein markers associated with the suppression of T cell activity. Our preliminary results suggest that these compounds may function to down-modulate ongoing CD4 and CD8 immune activity, while, nevertheless, poising the T cells for a subsequent immune response. |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.186.supp.50.7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::20d905a54e0990bdc48b04f13f5dbd4b https://doi.org/10.4049/jimmunol.186.supp.50.7 |
| رقم الانضمام: | edsair.doi...........20d905a54e0990bdc48b04f13f5dbd4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.186.supp.50.7 |