Amino Steroids - 12-Oxygenated Heteroconanine Derivatives. Preparation and Properties
| العنوان: | Amino Steroids - 12-Oxygenated Heteroconanine Derivatives. Preparation and Properties |
|---|---|
| المؤلفون: | G. Van De Woude, Monique Biesemans, L. van Hove |
| المصدر: | Bulletin des Sociétés Chimiques Belges. 91:249-259 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Potassium hydroxide, Base (chemistry), chemistry.chemical_element, General Chemistry, Oxygen, chemistry.chemical_compound, chemistry, Boiling, Hofmann elimination, Organic chemistry, Degradation (geology), Epimer, Ethylene glycol |
| الوصف: | Treatment of N-methyl-5α-conaninium iodides, diversely oxygenated at position 12, with a boiling solution of potassium hydroxide in ethylene glycol most often appears to be a satisfactory method to obtain the title compounds. The latter are free bases of reversed configuration at C-20 with regard to the starting compounds. The conversion is however never complete: the conanine base and an isomer of the normal Hofmann elimination product are always formed, occasionally together with minor degradation products. Comparison of the properties of heteroconan-3β-ols carrying an oxygen function at C-12 with those of the corresponding conan-3β-ols revealed differences which can be used as rules to distinguish the epimers of a pair. Deviations from the generally observed regularities seem to be dependent on the nature of the oxygen function located at C-12. |
| تدمد: | 0037-9646 |
| DOI: | 10.1002/bscb.19820910311 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2061c5fabb844c20a5e46f5369efed8b https://doi.org/10.1002/bscb.19820910311 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........2061c5fabb844c20a5e46f5369efed8b |
| قاعدة البيانات: | OpenAIRE |
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