Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using 68Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden
| العنوان: | Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using 68Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden |
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| المؤلفون: | James T. Thackeray, Hans-Juergen Wester, Thorsten Derlin, Tobias L. Ross, Saskia Kropf, Frank M. Bengel, Guenter Daum, Jan M Sohns, Desiree Weiberg |
| المصدر: | Journal of Nuclear Medicine. 59:266-272 |
| بيانات النشر: | Society of Nuclear Medicine, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | PET-CT, Cell type, Pathology, medicine.medical_specialty, business.industry, Cardiovascular risk factors, 030204 cardiovascular system & hematology, medicine.disease_cause, CXCR4, Vulnerable plaque, 030218 nuclear medicine & medical imaging, Correlation, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Medicine, Radiology, Nuclear Medicine and imaging, Molecular imaging, business |
| الوصف: | The CXC-motif chemokine receptor 4 (CXCR4) represents a promising target for molecular imaging of different CXCR4-positive cell types in cardiovascular diseases such as atherosclerosis and arterial wall injury. The aim of this study was to assess the prevalence, pattern, and clinical correlates of arterial wall accumulation of 68Ga-pentixafor, a specific CXCR4 ligand for PET. Methods: The data for 51 patients who underwent 68Ga-pentixafor PET/CT for noncardiovascular indications were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed qualitatively and semiquantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with calcified plaque burden and cardiovascular risk factors. Results: Focal arterial uptake of 68Ga-pentixafor was seen at 1,411 sites in 51 (100%) of patients. 68Ga-pentixafor uptake was significantly associated with calcified plaque burden (P < 0.0001) and cardiovascular risk factors including age (P < 0.0001), arterial hypertension (P < 0.0001), hypercholesterolemia (P = 0.0005), history of smoking (P = 0.01), and prior cardiovascular events (P = 0.0004). Both the prevalence (P < 0.0001) and the signal intensity (P = 0.009) of 68Ga-pentixafor uptake increased as the number of risk factors increased. Conclusion:68Ga-pentixafor PET/CT is suitable for noninvasive, highly specific PET imaging of CXCR4 expression in the atherosclerotic arterial wall. Arterial wall 68Ga-pentixafor uptake is significantly associated with surrogate markers of atherosclerosis and is linked to the presence of cardiovascular risk factors. 68Ga-pentixafor signal is higher in patients with a high-risk profile and may hold promise for identification of vulnerable plaque. |
| تدمد: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.117.196485 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1fe530c29ade662cf19b41245be03c77 https://doi.org/10.2967/jnumed.117.196485 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........1fe530c29ade662cf19b41245be03c77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2159662X 01615505 |
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| DOI: | 10.2967/jnumed.117.196485 |