Allergic bronchopulmonary aspergillosis as aetiology of bronchiectasis: data from the German bronchiectasis registry PROGNOSIS

التفاصيل البيبلوغرافية
العنوان: Allergic bronchopulmonary aspergillosis as aetiology of bronchiectasis: data from the German bronchiectasis registry PROGNOSIS
المؤلفون: Felix C. Ringshausen, Pontus Mertsch, Andrés de Roux, Jessica Rademacher, Grit Barten-Neiner, Tobias Welte, Isabell Pink, Annegret Zurawski, Roland Diel
المصدر: Respiratory infections.
بيانات النشر: European Respiratory Society, 2020.
سنة النشر: 2020
مصطلحات موضوعية: medicine.medical_specialty, Bronchiectasis, Exacerbation, business.industry, Significant difference, Mean age, Disease, medicine.disease, Chronic disease, Internal medicine, medicine, Etiology, Allergic bronchopulmonary aspergillosis, business
الوصف: Bronchiectasis is a chronic disease with a variety of aetiologies that influence the clinical presentation and management of the disease. One of these aetiologies is allergic bronchopulmonary aspergillosis (ABPA). Methods: 27 of 1000 patients (2.7%) included in PROGNOSIS had ABPA as aetiology of bronchiectasis (per investigator judgment). ABPA testing was the most common aetiological test performed in 58% of subjects. Comparison was made to 973 adults with bronchiectasis caused by any other aetiology. Results: Mean age was 63 years in ABPA compared to 61 years (p=0.410), 37% were male (vs 41%; p=0.694). Median annual exacerbation rate was 2 (each; p=0.47). Although mean ppFEV1 differed from 59.7% (95% CI: 52.5-77.0) to 70.6% (95% CI: 66.9-71.3), there was no significant difference (p=0.842). Radiological features showed predominant involvement of upper lobes (left 70.4% vs. 35.5%, p Method: Adults with ABPA as aetiology of bronchiectasis show mainly upper lobe involvement and cystic bronchiectasis with no differences in frequency of positive fungal cultures. The majority is treated with OCS, only two-thirds received ICS, antimycotics were infrequently used. Further research is warranted, especially as ABPA is considered a treatable trait in bronchiectasis.
DOI: 10.1183/13993003.congress-2020.2307
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1fb0d24a266d4f22c3b4f7bac4c285be
https://doi.org/10.1183/13993003.congress-2020.2307
رقم الانضمام: edsair.doi...........1fb0d24a266d4f22c3b4f7bac4c285be
قاعدة البيانات: OpenAIRE
الوصف
DOI:10.1183/13993003.congress-2020.2307