In silico screening of anti-inflammatory constituents with good drug-like properties from twigs of Cinnamomum cassia based on molecular docking and network pharmacology
| العنوان: | In silico screening of anti-inflammatory constituents with good drug-like properties from twigs of Cinnamomum cassia based on molecular docking and network pharmacology |
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| المؤلفون: | Chunjie Wu, Jia Liu, Wei Peng, Xufeng Pu, Qing Zhang, Ruolan Li, Yongxiang Gao |
| المصدر: | Tropical Journal of Pharmaceutical Research. 18:2125-2131 |
| بيانات النشر: | African Journals Online (AJOL), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biology, Chemistry, In silico, Pharmaceutical Science, Computational biology, biology.organism_classification, Ligand (biochemistry), Cassia, OMIM : Online Mendelian Inheritance in Man, Pharmacology (medical), Target protein, DrugBank, Cinnamomum, Discovery Studio |
| الوصف: | Purpose: To investigate by in silico screening the anti-inflammatory constituents of Cinnamomum cassia twigs. Methods: Information on the constituents of C. cassia twigs was retrieved from the online Traditional Chinese Medicines (TCM) database and literature. Inflammation-related target proteins were identified from DrugBank, Online Mendelian Inheritance in Man (OMIM), Therapeutic Target Database (TTD), Genetic Association Database (GAD), and PharmGKB. The identified compounds were filtered by Lipinski’s rules with Discovery Studio software. The “Libdock” module was used to perform molecular docking; LibdockScores and default cutoff values for hydrogen bonds and van der Waals interactions were recorded. LibdockScores between the prototype ligand and target protein were set as the threshold; compounds with higher LibdockScores than threshold were regarded as active compounds. Cytoscape software was used to construct active constituent-target protein interaction networks. Results: Sixty-nine potential inflammatory constituents with good drug-like properties in C. cassia twigs were screened in silico based on molecular docking and network pharmacology analysis. JAK2, mPEGS-1, COX-2, IL-1β, and PPARγ were considered the five most important target proteins. Compounds such as methyl dihydromelilotoside, hierochin B, dihydromelilotoside, dehydrodiconiferyl alcohol, balanophonin, phenethyl (E)-3-[4-methoxyphenyl]-2-propenoate, quercetin, and luteolin each interacted with more than six of the selected target proteins. Conclusion: C. cassia twigs possess active compounds with good drug-like properties that can potentially be developed to treat inflammation with multi-components on multi-targets. |
| تدمد: | 1596-9827 1596-5996 |
| DOI: | 10.4314/tjpr.v18i10.18 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1d3a6b2f95a233f6929d21ceca6fdaf7 https://doi.org/10.4314/tjpr.v18i10.18 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........1d3a6b2f95a233f6929d21ceca6fdaf7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15969827 15965996 |
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| DOI: | 10.4314/tjpr.v18i10.18 |