Development of a Large-Scale Asymmetric Process for tert-Butanesulfinamide
| العنوان: | Development of a Large-Scale Asymmetric Process for tert-Butanesulfinamide |
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| المؤلفون: | Denis Byrne, Zhengxu S. Han, Philomen DeCroos, Bo Qu, Frank Roschangar, Larry Nummy, Yibo Xu, Jinhua J. Song, Jon C. Lorenz, Ling Wu, Chris H. Senanayake, Kanwar Sidhu, Heewon Lee |
| المصدر: | Organic Process Research & Development. 23:263-268 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Reaction conditions, Chemical substance, Lithium amide, 010405 organic chemistry, Scale (chemistry), Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Transfer agent, Reagent, Scientific method, tert-Butanesulfinamide, Physical and Theoretical Chemistry |
| الوصف: | Process development for a scalable and green synthesis of chiral tert-butanesulfinamide (TBSA) on a multikilogram scale is reported. The process is based on the identification of a chiral sulfinyl transfer agent, benzo[1,3]oxathiozin-2-one, that contains active and differentiated S–N and S–O bonds, allowing the synthesis to proceed under mild reaction conditions. This method is practical and overcomes the disadvantages of earlier methods deploying harsh reaction conditions and hazardous and toxic reagents. |
| تدمد: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.8b00399 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1afdd5f0b1773f3abbf934a4948f431c https://doi.org/10.1021/acs.oprd.8b00399 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........1afdd5f0b1773f3abbf934a4948f431c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520586X 10836160 |
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| DOI: | 10.1021/acs.oprd.8b00399 |