التفاصيل البيبلوغرافية
| العنوان: |
PlexinA2 forward signaling through Rap1 GTPasesregulates dentate gyrus development andSchizophrenia-like behaviors |
| المؤلفون: |
Zhao, XF, Kohen, R, Parent, R, Duan, Y, Fisher, GL, Korn, MJ, Ji, L, Wan, G, Jin, J, Püschel, AW, Dolan, DF, Parent, JM, Corfas, G, Murphy, GG, Giger, RJ |
| بيانات النشر: |
My University, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Rap1, fear memory, sensorimotor gating, GAP, Nerve Tissue Proteins, Receptors, Cell Surface, GTP Phosphohydrolases, adult neurogenesis, schizophrenia, Mice, mossy fiber, Dentate Gyrus, PlexinA2, Animals, Humans, semaphoring, Signal Transduction |
| الوصف: |
Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs is regulated by Sema5A signaling through PlxnA2 and requires a functional PlxnA2 GTPase-activating protein (GAP) domain and Rap1 small GTPases. In adult Plxna2−/− but not Plxna2-GAP-deficient mice, the dentate GC layer is severely malformed, neurogenesis is compromised, and mossy fibers form aberrant synaptic boutons within CA3. Behavioral studies with Plxna2−/− mice revealed deficits in associative learning, sociability, and sensorimotor gating—traits commonly observed in neuropsychiatric disorder. Remarkably, while morphological defects are minimal in Plxna2-GAP-deficient brains, defects in fear memory and sensorimotor gating persist. Since allelic variants of human PLXNA2 and RAP1 associate with schizophrenia, our studies identify a biochemical pathway important for brain development and mental health. Zhao et al. find that Sema5A-PlexinA2 forward signaling through Rap1 GTPases is required for progenitor distribution in the developing mouse dentate gyrus. Adult Plxna2−/−, but not Plxna2-GAP-deficient, mice show defects in dentate morphology, neurogenesis, and mossy fiber connectivity. Plxna2−/− and Plxna2-GAP mice exhibit behavioral defects suggestive of neuropsychiatric illness. |
| DOI: |
10.7302/7119 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5835e125295023c801ae1eeb508fdc |
| رقم الانضمام: |
edsair.doi...........1a5835e125295023c801ae1eeb508fdc |
| قاعدة البيانات: |
OpenAIRE |