Crosslinked carboxymethyl cellulose-SiO2 hidrogels fabrication: Composition and thermal stability towards biomedical applications

التفاصيل البيبلوغرافية
العنوان: Crosslinked carboxymethyl cellulose-SiO2 hidrogels fabrication: Composition and thermal stability towards biomedical applications
المؤلفون: David Patiño-Ruiz
المصدر: IPSA Scientia, revista científica multidisciplinaria. 5:60-71
بيانات النشر: Biteca, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Thermogravimetric analysis, Materials science, technology, industry, and agriculture, Nanoparticle, macromolecular substances, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Carboxymethyl cellulose, chemistry.chemical_compound, chemistry, Chemical engineering, Self-healing hydrogels, medicine, Thermal stability, Particle size, Fourier transform infrared spectroscopy, 0210 nano-technology, Carbodiimide, medicine.drug
الوصف: Novel and innovative materials for biomedical and pharmaceutical applications have to consider several factors during their fabrication, such as the material composition and thermal stability, aiming to establish the promising physicochemical properties towards efficient and controlled drug release systems. In this study, carboxymethyl cellulose (CMC) hydrogels are prepared by incorporating silica dioxide (SiO2) nanoparticles previously modified with primary amine (-NH2) functional groups. The carbodiimide chemistry method is performed to promote the crosslinking of the CMC structure through the formation of amide bonds from the activation of carboxyl (C=O) groups and further covalent binding with -NH2 groups. The morphology information displays high dispersed SiO2 nanoparticles with a smooth surface, regular shape, and an average particle size of 104 nm. The material composition and thermal stability are evaluated using the Fourier transform infrared spectroscopy and thermogravimetric analysis to establish a preliminary overview of a functional hydrogel for biomedical and pharmaceutical applications. The formation of amide bonds is confirmed indicating the successful crosslinking of the CMC structure with SiO2-NH2 nanoparticles, which is attributed to the activation of the C=O groups and its strong affinity to the -NH2 groups. This interaction enhanced the thermal stability of the crosslinked CMC-SiO2 hydrogels up to 469°C which was the last decomposition event, outstanding the contribution of major content of SiO2-NH2 nanoparticles. These preliminary results suggest a suitable procedure for the fabrication of crosslinked CMC-SiO2 hydrogels as novel materials with promising physicochemical properties, allowing to proceed with further research works related to the controlled drug release and delivery.
تدمد: 2744-8355
2711-4406
DOI: 10.25214/27114406.935
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::196a47ea20b5d00eca31c9697201ad19
https://doi.org/10.25214/27114406.935
Rights: OPEN
رقم الانضمام: edsair.doi...........196a47ea20b5d00eca31c9697201ad19
قاعدة البيانات: OpenAIRE
الوصف
تدمد:27448355
27114406
DOI:10.25214/27114406.935