Most existing methods using hyperspectral imaging (HSI) to estimate skin chromophore concentrations fail to give an account of scattering properties crucial to many medical applications. To address this limitation, we propose to combine HSI with spatial frequency domain imaging (SFDI). Total acquisition time is around five seconds, making the process suitable for in vivo application. Skin absorption and scattering analysis is performed from these images by successive optimizations on the absorption and scattering properties. The problem of shadows occurring on complex shapes such as the face is addressed by an original approach that make results robust to irradiance drift.