التفاصيل البيبلوغرافية
| العنوان: |
Association of Interleukin-1 beta and tumor necrosis factor-alpha genetic polymorphisms with gastric cancer in India |
| المؤلفون: |
Arup Kumar Pattanayak, Debmalya Sengupta, Makhan Lal Saha, Mainak Sengupta, Zareen Sultana, Chinmay Kumar Panda, Madhusudan Das, Biswabandhu Bankura |
| المصدر: |
Environmental and Molecular Mutagenesis. 59:653-667 |
| بيانات النشر: |
Wiley, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
medicine.medical_specialty, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Cancer, Mutagen, Single-nucleotide polymorphism, medicine.disease_cause, medicine.disease, Gastroenterology, Proinflammatory cytokine, Log-rank test, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Genotype, Medicine, 030211 gastroenterology & hepatology, Tumor necrosis factor alpha, Allele, business, Genetics (clinical) |
| الوصف: |
Interleukin 1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) are key inflammatory cytokines whose polymorphisms have been correlated with increased susceptibility to gastric cancer (GC). Since geographical and racial differences exist in cancer rates, our study was aimed to evaluate the first possible association of polymorphisms in these genes with GC risk in West Bengal, India. Polymorphisms in IL-1β and TNF-α genes were genotyped in 120 GC patients and 135 healthy individuals. Combined effect of the SNPs in both genes with GC risk was determined through allele dosage analysis (ADA) and the survival data were analyzed by Log Rank Test. The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p A, rs1799964: T > C (p C and rs16944: C > T and patient survivability. The presence of H. pylori enhanced the risk in individuals with IL-1β rs1143627:CC and rs16944:TT genotypes. Further, meta-analysis revealed significant association of IL-1β rs1143627: T > C (p = 0.026; OR = 4.165; 95% CI 1.18-14.65) and rs16944: C > T (p = 0.01; OR = 5.49; 95% CI 1.48-20.37) in presence of H. pylori with gastric cancer in Asian population though no significant difference (p > 0.05) was found when compared to absence of H. pylori Environ. Mol. Mutagen. 59:653-667, 2018. © 2018 Wiley Periodicals, Inc. |
| تدمد: |
0893-6692 |
| DOI: |
10.1002/em.22208 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::162c8a6c86a811bc25a44e5f0c9928d8
https://doi.org/10.1002/em.22208 |
| Rights: |
CLOSED |
| رقم الانضمام: |
edsair.doi...........162c8a6c86a811bc25a44e5f0c9928d8 |
| قاعدة البيانات: |
OpenAIRE |