Pathogen distribution and bacterial resistance in children with severe pneumonia
| العنوان: | Pathogen distribution and bacterial resistance in children with severe pneumonia |
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| المؤلفون: | De-Quan Su, Hong-Lin Huang, Zhi-Qiang Zhuo |
| المصدر: | Medicine. 100:e27128 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | business.industry, medicine.drug_class, Streptococcus, Antibiotics, General Medicine, Drug resistance, medicine.disease_cause, medicine.disease, Haemophilus influenzae, Microbiology, Pneumonia, Antibiotic resistance, Mycoplasma pneumonia, medicine, business, Pathogen |
| الوصف: | To examine the etiological distribution of pathogens in pediatric patients with severe pneumonia and analyze the drug resistance of major pathogen species.Nasopharyngeal secretion specimens were collected for bacterial culture from pediatric patients admitted to the Xiamen children's hospital who were diagnosed with severe pneumonia from January 2016 to December 2019. Pathogen species were detected by quantitative polymerase chain reaction, direct immunofluorescence, and bacterial culture and we examined the drug susceptibility of the bacterial pathogens.At least 1 species of the pathogen was detected in 576 of 734 patients and a total of 444 bacterial samples were isolated, of which 284 were gram-negative and 160 were gram-positive. The most frequently detected bacteria were Haemophilus influenzae, Streptococcus pneumonia, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. In addition, we isolated 186 viral samples, of which the majority were respiratory syncytial virus (n = 90) and adenovirus (n = 70) as well as 142 Mycoplasma pneumonia samples.Gram-negative bacteria are dominant among the pathogens causing severe pneumonia in pediatric patients and the major pathogen species are resistant to a variety of antibiotics. Appropriate antibiotic use has an important role in preventing the emergence of resistant strains. |
| تدمد: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000027128 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::160435584f3ec8e407ccc2620b704f6a https://doi.org/10.1097/md.0000000000027128 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........160435584f3ec8e407ccc2620b704f6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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| DOI: | 10.1097/md.0000000000027128 |