Base-catalyzed deuterium and tritium labelling of 1-biphenyl-4-ylpropane-1,2-dione and deuteration of aryl methyl ketones
| العنوان: | Base-catalyzed deuterium and tritium labelling of 1-biphenyl-4-ylpropane-1,2-dione and deuteration of aryl methyl ketones |
|---|---|
| المؤلفون: | Carl Berthelette, John Scheigetz |
| المصدر: | Journal of Labelled Compounds and Radiopharmaceuticals. 47:891-894 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Diketone, chemistry.chemical_classification, Ketone, Bicyclic molecule, Aryl, Organic Chemistry, Biochemistry, Chemical synthesis, Analytical Chemistry, chemistry.chemical_compound, Deuterium, chemistry, Drug Discovery, Organic chemistry, Radiology, Nuclear Medicine and imaging, Tritium, Spectroscopy, Methyl group |
| الوصف: | A synthesis and a base-catalyzed exchange reaction was developed under mild conditions to deuterate and subsequently tritiate the methyl group of the base sensitive diketone 1-biphenyl-4-ylpropane-l,2-dione depicted in Figure 1. Using Et3N as base, deuterium incorporation of the methyl group was 88.9% and the tritium incorporation gave a specific radioactivity of 119 mCi/mmol. The scope of the exchanges was extended to methyl aryl ketones 2–4. Copyright © 2004 John Wiley & Sons, Ltd. |
| تدمد: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.879 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1433c861823721fc3c22485efcddedc5 https://doi.org/10.1002/jlcr.879 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........1433c861823721fc3c22485efcddedc5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991344 03624803 |
|---|---|
| DOI: | 10.1002/jlcr.879 |