A 3-Day Functional Unloading is Accompanied by an Increase in the TTN Gene Expression in the Rat Soleus Muscle without Changes in Alternative Splicing from Exon 50 to Exon 111
| العنوان: | A 3-Day Functional Unloading is Accompanied by an Increase in the TTN Gene Expression in the Rat Soleus Muscle without Changes in Alternative Splicing from Exon 50 to Exon 111 |
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| المؤلفون: | L. G. Bobyleva, T. L. Nemirovskaya, Ivan M. Vikhlyantsev, S. P. Belova, Yu. V. Gritsyna, V. K. Zhalimov, Boris Shenkman, A. D. Ulanova |
| المصدر: | Biophysics. 64:683-689 |
| بيانات النشر: | Pleiades Publishing Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Soleus muscle, Control level, Messenger RNA, 030102 biochemistry & molecular biology, biology, Chemistry, Alternative splicing, Biophysics, musculoskeletal system, Molecular biology, 03 medical and health sciences, Exon, 030104 developmental biology, Gene expression, biology.protein, Titin, tissues |
| الوصف: | —Changes in the expression of the titin gene and alternative splicing of titin pre-mRNA from exon 50 to exon 111 in rat soleus muscle were analyzed following 3-day functional unloading (the HS group). Using real-time RT-PCR, it was found that the expression level of the titin gene in the rat soleus muscle from the HS group was higher by 1.81 times (p ≤ 0.01, n = 6) than the control level (n = 7). It was shown that all studied exons of titin mRNA are present in rats soleus muscle from the two groups. Our results demonstrate that 3-day functional unloading is accompanied by an increase in the expression of the titin gene in rat soleus without changes in alternative splicing from exon 50 to exon 111. |
| تدمد: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350919050245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::129cdd54d30618094e97af1918a2dac2 https://doi.org/10.1134/s0006350919050245 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........129cdd54d30618094e97af1918a2dac2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15556654 00063509 |
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| DOI: | 10.1134/s0006350919050245 |