LVPEI Glaucoma Epidemiology and Molecular Genetic Study: teleophthalmology screening for angle-closure disease in an underserved region
| العنوان: | LVPEI Glaucoma Epidemiology and Molecular Genetic Study: teleophthalmology screening for angle-closure disease in an underserved region |
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| المؤلفون: | Chandra S. Garudadri, Ganesh B. Jonnadula, Nikhil S. Choudhari, Premanand Chandran, Harsha L. Rao, Uday K. Addepalli, Sirisha Senthil |
| المصدر: | Eye. 34:1399-1405 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Percentile, Slit lamp, genetic structures, medicine.diagnostic_test, business.industry, Glaucoma, Teleophthalmology, medicine.disease, eye diseases, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Epidemiology, Combination strategy, 030221 ophthalmology & optometry, medicine, Gonioscopy, Cutoff, sense organs, business, 030217 neurology & neurosurgery |
| الوصف: | To assess the ability of teleophthalmoscopic grading of peripheral anterior chamber depth (PACD) using the van Herick (vH) technique in detecting gonioscopically occludable angle; and to determine whether combining results from vH grading and ocular biometry can improve the accuracy to diagnose gonioscopically occludable angle This cross-sectional study was an offshoot of a rural population-based study, Glaucoma Epidemiology and Molecular Genetic Study (GLEAMS). A masked urban ophthalmologist graded digital slit lamp photographs of PACD by vH technique. Sussman four-mirror lens was used to perform dark room indentation gonioscopy. Cutoff values of the tests were, vH technique: grade ≤ 2, central anterior chamber depth (ACD), as well as axial length: ≤ 25th percentile and lens thickness ≥ 75th percentile value of the study population. We studied 1965 eyes of 1029 adult participants. The vH grade was ≤2 in 188 (9.5%) eyes. The angle was occludable by gonioscopy in 101 (5.1%) eyes. The performance of the vH test to rule out gonioscopically occludable angle was good [negative predictive value (NPV): 97.3%], despite low sensitivity (52.5%), while its efficacy to rule in the condition was low [positive predictive value (PPV): 28.2%] despite high specificity (92.8%). However, test combination strategy increased the PPV nearly twofold (53.8%). The calculated PPV at 10% prevalence of gonioscopically occludable angle was even higher (70.5%). Van Herick technique can be incorporated into a teleophthalmology program by means of slit lamp photographs of PACD. Combined vH grading and ocular biometry improved the predictability of a gonioscopically occludable angle. |
| تدمد: | 1476-5454 0950-222X |
| DOI: | 10.1038/s41433-019-0666-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1184e7f218c66164eeea1ba8e83e723a https://doi.org/10.1038/s41433-019-0666-x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........1184e7f218c66164eeea1ba8e83e723a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765454 0950222X |
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| DOI: | 10.1038/s41433-019-0666-x |