Association of Functional Polymorphisms in Matrix Metalloproteinase-9 and Glutathione S-Transferase T1 Genes with Temporomandibular Disorders
| العنوان: | Association of Functional Polymorphisms in Matrix Metalloproteinase-9 and Glutathione S-Transferase T1 Genes with Temporomandibular Disorders |
|---|---|
| المؤلفون: | Irving Sucholeiki, Dara D. Fairchild, Sam A. Malekiani, Taleen Hanania, Scott Davis, Roy Sucholeiki, Andrew Hu, Michael A. Henry, Heather S. Hain, Mayur J. Patil, Darrell Nix |
| المصدر: | Journal of Oral & Facial Pain and Headache. 29:286-296 |
| بيانات النشر: | Quintessence Publishing, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Orofacial pain, Gabapentin, business.industry, Stimulation, medicine.disease, Infraorbital nerve, Anesthesiology and Pain Medicine, Allodynia, Anesthesia, Neuropathic pain, Hyperalgesia, Neuralgia, medicine, Dentistry (miscellaneous), Neurology (clinical), medicine.symptom, business, medicine.drug |
| الوصف: | Aims: To study the effects of a novel matrix metalloproteinase-2 (MMP-2) and MMP–9 inhibitor, AQU-118, on mechanical allodynia in the spinal nerve ligation (SNL) model of neuropathic pain and the chronic constriction injury of the infraorbital nerve (CCI-IoN) model of neuropathic orofacial pain. Methods: Five groups of SNL rats were given daily oral doses of AQU-118 (5, 10, 20 mg/kg), gabapentin (100 mg/kg), or vehicle (0.5% methylcellulose) and then paw withdrawal threshold was measured with von Frey filaments (VF). Three groups of CCI-IoN rats were given daily oral doses of either AQU-118 (40 mg/kg), gabapentin (100 mg/kg), or vehicle (0.5% methylcellulose) and then mechanical allodynia was measured with facial VF and non–reflex-based orofacial stimulation test (OFST) assay. Naive rats were also tested for the effect of AQU-118 (40 mg/kg) on basal sensitivity to mechanical stimulation/locomotive activity. Results: Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner). Mechanical allodynia in CCI-IoN rats was also attenuated (in an equipotent manner) by both AQU-118 (40 mg/ kg) and gabapentin (100 mg/kg) as measured by both facial VF and OFST assay. Upon cessation of either AQU-118 or gabapentin, VF-related responses in both models and OFST assay times reverted to levels observed in vehicle-treated rats. No statistically significant change was observed in locomotive activity/paw withdrawal threshold by AQU-118 (40 mg/kg) in naive rats. Conclusion: The results demonstrated that oral AQU-118 attenuates mechanical allodynia in both neuropathic pain models and with efficacies that mirror gabapentin at the 40 mg/kg dose used in the CCI-IoN model but without effect on basal sensitivity to mechanical stimulation/locomotive activity. These findings support a possible role for MMP-2/-9 in the etiology of neuropathic pain and also suggest that inhibition strategies represent a viable treatment option. |
| تدمد: | 2333-0376 2333-0384 |
| DOI: | 10.11607/ofph.1350 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::10eb654313b494505033d6cc6463e16e https://doi.org/10.11607/ofph.1350 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........10eb654313b494505033d6cc6463e16e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23330376 23330384 |
|---|---|
| DOI: | 10.11607/ofph.1350 |