Fractional laser microablation of skin: increasing the efficiency of transcutaneous delivery of particles
| العنوان: | Fractional laser microablation of skin: increasing the efficiency of transcutaneous delivery of particles |
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| المؤلفون: | Valery V. Tuchin, Elina A. Genina, Alexey N. Bashkatov, Leonid E. Dolotov |
| المصدر: | Quantum Electronics. 46:502-509 |
| بيانات النشر: | IOP Publishing, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Shock wave, Materials science, medicine.medical_treatment, Fractional laser, 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, Optics, Optical coherence tomography, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, medicine, Electrical and Electronic Engineering, medicine.diagnostic_test, business.industry, Tio2 nanoparticles, Statistical and Nonlinear Physics, Penetration (firestop), Ablation, Laser, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Particle penetration, 020201 artificial intelligence & image processing, business, Biomedical engineering |
| الوصف: | We study several regimes of fractional laser microablation using a pulsed Er : YAG laser for producing microchannels of different depth and incisions that allow transcutaneous delivery of particles of different size, namely, Al2O3 (27 μm), ZrO2 (smaller than 5 μm) and TiO2 (smaller than 100 nm). The shock wave regime was used both for enhancing the penetration of particles into the ablation zones and as an independent method of particle delivery into the skin. Based on optical coherence tomography we assessed the coherent depth of particle detection in the skin in 2 hours, 3 days and 10 days after the administration. The maximal localisation depth (up to 450 μm) was obtained for TiO2 nanoparticles in the regime of incisions with enhancement of particle penetration by pulses of a multiple-beam hydrodynamic shock wave. The results of the study can be useful for developing new methods of transcutaneous delivery of micro- and nanocarriers of medicinal preparations. |
| تدمد: | 1468-4799 1063-7818 |
| DOI: | 10.1070/qel16109 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0c9e6723c701a397b42c9c8e3f6aecac https://doi.org/10.1070/qel16109 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........0c9e6723c701a397b42c9c8e3f6aecac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14684799 10637818 |
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| DOI: | 10.1070/qel16109 |