Distinct sulfated glycans expressed in intrahepatic cholangiocarcinoma: a potential target for new therapy
| العنوان: | Distinct sulfated glycans expressed in intrahepatic cholangiocarcinoma: a potential target for new therapy |
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| المؤلفون: | Hitomi Hoshino, Motohiro Kobayashi |
| المصدر: | Immunotherapy. 15:503-516 |
| بيانات النشر: | Future Medicine Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Oncology, Immunology, Immunology and Allergy |
| الوصف: | Cholangiocytes exhibit morphological and functional heterogeneity, depending on their anatomical localization; however, like other ductal organs, their mucosal surface is covered with mucin, which functions to prevent the entry of foreign substances, lubricate and prevent clogging by bile. Recently, the authors discovered that distinct sulfated glycans recognized by a series of antisulfated glycan antibodies are expressed not only in normal intrahepatic bile ducts but also in intrahepatic cholangiocarcinoma (iCCA). In this review, the authors first describe the anatomy of bile ducts and the biochemical characteristics of bile-duct-associated mucins, and then describe differences in structure and expression patterns of these sulfated glycans in physiological and pathological conditions. Finally, potential therapeutic strategies for iCCA using antisulfated glycan antibodies are discussed. |
| تدمد: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt-2022-0220 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0ba32b62864577a17ccdaf8c34d41514 https://doi.org/10.2217/imt-2022-0220 |
| رقم الانضمام: | edsair.doi...........0ba32b62864577a17ccdaf8c34d41514 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17507448 1750743X |
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| DOI: | 10.2217/imt-2022-0220 |