Artemether–Lumefantrine and Dihydroartemisinin–Piperaquine Retain High Efficacy for Treatment of Uncomplicated Plasmodium falciparum Malaria in Myanmar
| العنوان: | Artemether–Lumefantrine and Dihydroartemisinin–Piperaquine Retain High Efficacy for Treatment of Uncomplicated Plasmodium falciparum Malaria in Myanmar |
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| المؤلفون: | Kyin Hla Aye, M. R. Rahman, Khin Lin, Maria Dorina Bustos, Zay Yar Han, Mya Moe, Moe Kyaw Myint, Pascal Ringwald, Christopher V. Plowe, Christine F. Markwalter, Aung Thi, Ryan A. Simmons, Kay Thwe Han, Myaing M. Nyunt |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 102:598-604 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Artemether/lumefantrine, biology, Combination therapy, business.industry, 030231 tropical medicine, Plasmodium falciparum, Parasitemia, biology.organism_classification, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Dihydroartemisinin/piperaquine, Virology, Internal medicine, parasitic diseases, medicine, Parasitology, Artemether, Artemisinin, business, Malaria, medicine.drug |
| الوصف: | The emergence of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion threatens both the efficacy of artemisinin-based combination therapy (ACT), the first-line treatment for malaria, and prospects for malaria elimination. Monitoring of ACT efficacy is essential for ensuring timely updates to elimination policies and treatment recommendations. In 2014-2015, we assessed the therapeutic efficacies of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for the treatment of uncomplicated P. falciparum at three study sites in Rakhine, Shan, and Kachin states in Myanmar. Patients presenting with uncomplicated P. falciparum malaria were enrolled, treated, and followed up for 28 days for AL or 42 days for DP. Both AL and DP demonstrated good therapeutic efficacy at all three study sites. The 28-day cure rate for AL was > 96% across all study sites, and the 42-day cure rate for DP was 100%. Parasitemia on day 3 was detected in 0%, 3.3%, and 3.6% of participants treated with AL at the Rakhine, Shan, and Kachin sites, respectively. No participants treated with DP were parasitemic on day 3. No evidence of P. falciparum k13 mutations was found at the Rakhine study site. A high prevalence of k13 mutations associated with artemisinin resistance was observed at the Kachin and Shan state study sites. These results confirm that ACT efficacy has been resilient in therapeutic efficacy study (TES) sentinel sites in Myanmar, despite the presence at some sites of k13 mutations associated with resistance. Studies are ongoing to assess whether this resilience persists. |
| تدمد: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.19-0692 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0af1530b1b8c364538fb603992ab322e https://doi.org/10.4269/ajtmh.19-0692 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........0af1530b1b8c364538fb603992ab322e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.19-0692 |