Introduction
| العنوان: | Introduction |
|---|---|
| المؤلفون: | M Aubier, G Boussignac, D Pinquier, F Beaufils, D Pavlovic |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 154:S82-S83 |
| بيانات النشر: | American Thoracic Society, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Mechanical ventilation, Artificial ventilation, Insufflation, business.industry, Dead space, medicine.medical_treatment, Positive pressure, Peak inspiratory pressure, Critical Care and Intensive Care Medicine, medicine.disease, Pneumothorax, Anesthesia, Respiration, medicine, business |
| الوصف: | Mechanical ventilation using a modified endotracheal tube, allowing bypass and washout of the endotracheal dead space (McETV), was compared with conventional controlled mechanical ventilation (CMV) in healthy and in surfactant-depleted rabbits. In healthy animals, shifting from CMV to McETV led to an increase in PaO2 (89 +/- 16 versus 104 +/- 13 mm Hg; p < 0.05) and a decrease in PaCO2 (41.5 +/- 3 versus 30 +/- 3 mm Hg; p < 0.05). As a result of reducing the peak inspiratory pressure (PIP) from 21 +/- 2 to 12 +/- 2 cm H2O (p < 0.05), it was possible in McETV mode to maintain comparable ventilation to that achieved by CMV. In surfactant-depleted animals, compared with CMV, McETV produced a rise in PaO2 without change in thoracic volume (from 100 +/- 40 to 150 +/- 60 mm Hg, p < 0.05) and a fall in PaCO2 (from 46 +/- 5 to 37 +/- 4 mm Hg, p < 0.05). After 4 h of ventilation, the surfactant-depleted animals from the CMV group developed thoracic overdistension quicker (at hour 1, p < 0.05) and, consequently, more animals died from pneumothorax compared with the McETV group (five versus two). We concluded that McETV ensured adequate gas exchanges with lower insufflation pressures and could diminish positive pressure ventilation-induced injury. |
| تدمد: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm/154.3_pt_2.s82 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0859c413c8b80aef773e18c267343aa8 https://doi.org/10.1164/ajrccm/154.3_pt_2.s82 |
| رقم الانضمام: | edsair.doi...........0859c413c8b80aef773e18c267343aa8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
|---|---|
| DOI: | 10.1164/ajrccm/154.3_pt_2.s82 |