Lipase-Catalyzed Solid-Phase Synthesis of Sugar Esters, IV: Selectivity of Lipases Towards Primary and Secondary Hydroxyl Groups in Carbohydrates
| العنوان: | Lipase-Catalyzed Solid-Phase Synthesis of Sugar Esters, IV: Selectivity of Lipases Towards Primary and Secondary Hydroxyl Groups in Carbohydrates |
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| المؤلفون: | Uwe T. Bornscheuer, Rolf D. Schmid, Linqiu Cao |
| المصدر: | Biocatalysis and Biotransformation. 16:249-257 |
| بيانات النشر: | Informa UK Limited, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | chemistry.chemical_classification, biology, Triacylglycerol lipase, Fatty acid, Fructose, biology.organism_classification, Biochemistry, Catalysis, Palmitic acid, Acylation, chemistry.chemical_compound, chemistry, biology.protein, Organic chemistry, lipids (amino acids, peptides, and proteins), Candida antarctica, Lipase, Selectivity, Biotechnology |
| الوصف: | The acylation of several pyranoses and fructose with fatty acids by lipases in a solid-phase system was investigated. Highest selectivity was found using lipase from Candida antarctica B immobilized on polypropylene EP 100. For β-D(+)-glucose 98% mono- and 2% diacylation using palmitic acid in t-butanol were observed. Much lower selectivities were achieved with D-(+)-mannose (75% monoacylation) and D(+)-galactose (50% monoacylation), which was explained by the different orientation of the C2-hydroxyl groups. The selectivity in the acylation of fructose was significantly influenced by the fatty acid chain length and the organic solvent. Monoacylation was favored in less hydrophobic solvents (e.g. t-butanol) using long chain fatty acids. |
| تدمد: | 1029-2446 1024-2422 |
| DOI: | 10.3109/10242429809003620 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0677dea571a51fee6be927aae2cc0261 https://doi.org/10.3109/10242429809003620 |
| رقم الانضمام: | edsair.doi...........0677dea571a51fee6be927aae2cc0261 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292446 10242422 |
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| DOI: | 10.3109/10242429809003620 |