Enantioselective Direct Aldol Reactions of Achiral Ketones with Racemic Enolizable α-Substituted Aldehydes: Scope and Limitations
| العنوان: | Enantioselective Direct Aldol Reactions of Achiral Ketones with Racemic Enolizable α-Substituted Aldehydes: Scope and Limitations |
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| المؤلفون: | Athanasios Karagiannis, Garrison E. Beye, Vishal Jheengut, Fabiola Becerril-Jiménez, Dale E. Ward, H. Martin Gillis |
| المصدر: | Synlett. 2011:508-512 |
| بيانات النشر: | Georg Thieme Verlag KG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Ketone, chemistry, Aldol reaction, Organocatalysis, Organic Chemistry, Enantioselective synthesis, Organic chemistry, Aldol condensation, Enantiomeric excess, Aldehyde, Kinetic resolution |
| الوصف: | Aldol reactions of racemic enolizable dioxolan-protected α-substituted-β-ketoaldehydes with representative achiral ketones catalyzed by proline or 5-(2-pyrrolidine-2-yl)-1H-tetrazole in wet DMSO proceed with dynamic kinetic resolution (or via DYKAT with an α-substituted-β-alkoxyaldehyde) to give adducts with high dr and ee. |
| تدمد: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0030-1259525 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::04d479b82d64325f1dbb822ca2e9ee56 https://doi.org/10.1055/s-0030-1259525 |
| رقم الانضمام: | edsair.doi...........04d479b82d64325f1dbb822ca2e9ee56 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14372096 09365214 |
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| DOI: | 10.1055/s-0030-1259525 |