التفاصيل البيبلوغرافية
| العنوان: |
Data from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity |
| المؤلفون: |
Robin L. Anderson, Bedrich L. Eckhardt, Jai Rautela, Cameron N. Johnstone, Belinda S. Parker, Bradley N. Bidwell, Clare Y. Slaney, Yuan Cao |
| بيانات النشر: |
American Association for Cancer Research (AACR), 2023. |
| سنة النشر: |
2023 |
| الوصف: |
The TGFβ growth factor family member BMP4 is a potent suppressor of breast cancer metastasis. In the mouse, the development of highly metastatic mammary tumors is associated with an accumulation of myeloid-derived suppressor cells (MDSC), the numbers of which are reduced by exogenous BMP4 expression. MDSCs are undetectable in naïve mice but can be induced by treatment with granulocyte colony-stimulating factor (G-CSF/Csf3) or by secretion of G-CSF from the tumor. Both tumor-induced and G-CSF–induced MDSCs effectively suppress T-cell activation and proliferation, leading to metastatic enhancement. BMP4 reduces the expression and secretion of G-CSF by inhibiting NF-κB (Nfkb1) activity in human and mouse tumor lines. Because MDSCs correlate with poor prognosis in patients with breast cancer, therapies based on activation of BMP4 signaling may offer a novel treatment strategy for breast cancer. Cancer Res; 74(18); 5091–102. ©2014 AACR. |
| DOI: |
10.1158/0008-5472.c.6505787 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::041d2c19a046ef8c1fa46aa3869b815f
https://doi.org/10.1158/0008-5472.c.6505787 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi...........041d2c19a046ef8c1fa46aa3869b815f |
| قاعدة البيانات: |
OpenAIRE |