Objective: This study aims to identify the determinants of Low Birth Weight (LBW) in Bahteramas General Hospital, Southeast Sulawesi Province, Indonesia. Method: This research uses an institutional-based Case-Control Study design from May to June 2021 at the Bahteramas Hospital, Southeast Sulawesi Province. Data were collected from 134 samples of mothers giving birth, with 67 of them having babies with birth weight 2500 g (controls) using secondary data, namely medical records. Data were analyzed by univariate, bivariate with odds ratio test, and multivariate analysis with multiple logistic regression to identify the determinants of LBW.. Result: Based on the logistic regression analysis, it found that the mother's educational status variable was ≤12 years [AOR 0.19 (95% CI 0.06-0.62)]; mothers with parity one or >3 [AOR 0.06 (95% CI 0.01-0.21)]; birth spacing