Objective To explore the value of application of immediate coagulation monitor, with the use of Sonoclot analyzer in the treatment of disseminated intravascular coagulation (DIC). Methods Two hundred and thirty-seven DIC patients were randomly divided into Sonoclot group (n=116, guided by Sonoclot analyzer) and control group (n=121, guided by traditional coagulation indexes) according to the principle of random number. The type, dose and duration of replacement treatment, and the outcomes such as complication rate, ICU stay and 30-day survival rate were recorded and compared. Results There were no difference in the demographic data between two groups (P>0.05). In Sonoclot group, the ratio of heparin used was much higher, though with shorter duration and lower dose than those in control group (P