Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to severe acute respiratory syndrome (SARS) coronavirus, can bind to angiotensin converting enzyme 2 (ACE2) receptor, damage multiple organs and is more contagious. Clinical studies have found that patients with cardiovascular disease are more susceptible to coronavirus disease 2019 (COVID-19), and are more prone to develop severe disease after infection and have a poor prognosis. Since patients with cardiovascular disease have more ACE2 receptors, are more prone to vascular endothelial damage, while patients with COVID often have increased plasma angiotensin Ⅱ and inflammatory factors, hypoxia in body and myocardium, and blood coagulation dysfunction, so that the overall disease aggravated. At present, there is insufficient research on the specific mechanism of the interaction between COVID and cardiovascular disease (especially the mechanism of increased susceptibility to COVID in patients with cardiovascular disease). In present paper, the characteristics of the SARS-CoV-2, the susceptibility, and the concurrent characteristics of the underlying diseases are discussed, which provides reference suggestions for the next clinical and experimental steps. DOI: 10.11855/j.issn.0577-7402.2020.05.05