Evaluation of biomarkers in pediatric patients with leishmaniosis and onco-hematological
| العنوان: | Evaluation of biomarkers in pediatric patients with leishmaniosis and onco-hematological |
|---|---|
| المؤلفون: | Costa, Flávia Oliveira da |
| المساهمون: | Silva, Angela Maria da |
| المصدر: | Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS |
| بيانات النشر: | Universidade Federal de Sergipe, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Visceral leishmaniasis, Onco-hematology, Biomarcadores, Neutropenia, CIENCIAS DA SAUDE [CNPQ], Crianças, Leishmaniose visceral, Child, Onco-hematologia, Biomarkers |
| الوصف: | Infection is the major complication for neutropenic patients, and cause of morbidity and mortality. Clinical signs are nonspecific and fever may be a late marker for the early use of antibiotics, which may complicate the prognosis. The approaches of most protocols focus on adult patients. Thus, to improve safety in the clinical approach in pediatric neutropenic patients, this work was performed in order to evaluate biomarkers involved in the inflammatory response in pediatric patients. In the period 2010 to 2012 were included 70 children with neutropenia with neutrophil count ≤ 1000 cells / mm ³, 35 pediatric patients with visceral leishmaniasis (VL) and 35 patients with onco-hematological disease, ranging in age from 0 to 18, from the oncology service of the Hospital Emergency ward Segipe and Pediatrics Diseases, University Hospital of Sergipe. Serum levels of biomarkers were evaluated following: Interferon gamma (IFN-γ), interleukin-5 (IL-5), interleukin-6 (IL-6), interleukin-10 (IL-10), lactate, ultrasensitive CRP (hsCRP), nprocalcitonina (PCT) and Tumor Necrosis Factor-α (TNF-α). The results showed that the average of the groups was no significant difference with biomarkers IFN-γ, IL-10 and TNF-α with p |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::83c92cf0195c9fa0d4dbce3f1fca0940 https://ri.ufs.br/handle/riufs/3807 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..83c92cf0195c9fa0d4dbce3f1fca0940 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |