Malva sylvestris L. Protects from Fluoride Nephrotoxicity in Rat
| العنوان: | Malva sylvestris L. Protects from Fluoride Nephrotoxicity in Rat |
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| المؤلفون: | Babaei Zarch, A., Hasan Fallah Huseini, Kianbakht, S., Changaei, P., Mirjalili, A., Salehi, J. |
| المصدر: | Journal of Medicinal Plants, Vol 16, Iss 61, Pp 21-32 (2017) Scopus-Elsevier |
| بيانات النشر: | Institue of Medicinal Plants, ACECR, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | nephrotoxicity, RA1190-1270, sodium fluoride, Toxicology. Poisons, malva sylvestris, rat, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Background: Malva sylvestris L. (M. sylvestris) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders. Objective: In this study, the protective effect of M. sylvestris against sodium fluoride-induced nephrotoxicity in the rat was evaluated. Methods: The M. sylvestris flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats’ kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control. Results: Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. M. sylvestris extract pretreatment significantly decreased the BUN and creatinine levels (P |
| اللغة: | English |
| تدمد: | 2717-2058 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::82e872da794af4902eb04af40ccb481c http://jmp.ir/article-1-1382-en.html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..82e872da794af4902eb04af40ccb481c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 27172058 |
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