The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
| العنوان: | The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans |
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| المؤلفون: | Wells, C. A., Salvage-Jones, J. A., Li, X., Hitchens, K., Butcher, S., Rachael Murray, Beckhouse, A. G., Lo, Y. L. S., Manzanero, S., Cobbold, C., Schroder, K., Ma, B., Orr, S., Stewart, L., Lebus, D., Sobieszczuk, P., Hume, D. A., Stow, J., Blanchard, H., Ashman, R. B. |
| المصدر: | Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y L, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 . < http://www.jimmunol.org/content/180/11/7404.short > The Journal of Immunology Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y-L-S, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 . Scopus-Elsevier ResearcherID |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Phagosomes/metabolism, Toll-Like Receptor 2/immunology, 060110 Receptors and Membrane Biology, Candida albicans/immunology, Lectins, C-Type/genetics, Macrophages/immunology, INCREASES SUSCEPTIBILITY, Cell Line, Mice, Phagocytosis, Phagosomes/immunology, Macrophages/metabolism, INFECTION, REVEALS, Animals, Humans, Candida albicans/metabolism, Lectins, C-Type/immunology, Toll-Like Receptor 2/metabolism, GENE-EXPRESSION, TOLL-LIKE RECEPTORS, GALECTIN-3, Mice, Knockout, Tumor Necrosis Factor-alpha/metabolism, DECTIN-1, Mice, Inbred BALB C, IDENTIFICATION, RECOGNITION, 110799 Immunology not elsewhere classified, Macrophages/cytology, Tumor Necrosis Factor-alpha/immunology, Immunity, Innate, Mice, Inbred C57BL, MURINE MACROPHAGES, Candidiasis/immunology, Disease Susceptibility, Lectins, C-Type/metabolism |
| الوصف: | The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7ea9e1e52e650a9340f8371b4f74cabb https://hdl.handle.net/20.500.11820/df0811c8-57ed-43df-9aa4-83dbf1dbabfe |
| Rights: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..7ea9e1e52e650a9340f8371b4f74cabb |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |