A Preliminary Study of the Potential of Tree Classifiers in Triage of High-Grade Squamous Intraepithelial Lesions
| العنوان: | A Preliminary Study of the Potential of Tree Classifiers in Triage of High-Grade Squamous Intraepithelial Lesions |
|---|---|
| المؤلفون: | Karakitsos, P., Pouliakis, A., Meristoudis, C., Niki Margari, Kassanos, D., Kyrgiou, M., Panayiotides, J. G., Paraskevaidis, E. |
| المصدر: | Web of Science Scopus-Elsevier |
| مصطلحات موضوعية: | Cervical Intraepithelial Neoplasia/*diagnosis/etiology/pathology, Algorithms, Humans, Female, Epithelial Cells/*pathology, Neoplasms, Squamous Cell/*diagnosis/etiology/pathology, Papillomavirus Infections/complications/pathology/virology, Uterine Cervical Neoplasms/*diagnosis/etiology/pathology |
| الوصف: | OBJECTIVE: To investigate the potential value of tree classifiers for the triage of high-grade squamous intraepithelial lesions. STUDY DESIGN: The dataset comprised 808 histologically confirmed cases having a complete range of the cytologic sample assessments--liquid-based cytology, reflex human papillomavirus (HPV) DNA test, E6/E7 HPV mRNA test, and p16 immunocytochemical examinations. Data include 488 histologically negative (cervical intraepithelial neoplasia [CIN] 1 and below) or clinically negative cases and 320 with histologic diagnosis of CIN 2 or worse. Cytologic diagnosis was made according to the criteria of the Bethesda System. Cases were classified in two groups according to histology: those with CIN 2 or worse and those with CIN 1 and below. Fifty percent were randomly selected as a training set and the remaining were as a test set. RESULTS: Application of tree classifier on the test set gave correct classification of 66.9% for CIN 2 and above cases and 97.3% for CIN 1 and below, producing overall accuracy of 91.5%, outperforming cytologic diagnosis alone. CONCLUSION: Application of tree classifiers, based on standard cytologic diagnosis and expression of studied biomarkers, produces improved classification results for cervical precancerous lesions and cancer diagnosis and Anal Quant Cytol Histol |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::63c767b500da56e7d73769379db482f7 https://publons.com/wos-op/publon/1573991/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..63c767b500da56e7d73769379db482f7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |