Real-world clinical effectiveness of rituximab rescue therapy in patients with progressive rheumatoid arthritis-related interstitial lung disease
| العنوان: | Real-world clinical effectiveness of rituximab rescue therapy in patients with progressive rheumatoid arthritis-related interstitial lung disease |
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| المؤلفون: | Narváez J, Robles-Pérez A, Molina-Molina M, Vicens-Zygmunt V, Luburich P, Yañez MA, Alegre JJ, Nolla JM |
| المصدر: | SEMINARS IN ARTHRITIS AND RHEUMATISM r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| بيانات النشر: | W B SAUNDERS CO-ELSEVIER INC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Treatment, Interstial lung disease, Rheumatoid arthritis, Rituximab |
| الوصف: | Objective: To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with progressive rheumatoid arthritis-related interstitial lung disease (RA-ILD) in whom more conventional therapy has failed. Methods: Longitudinal retrospective observational study of a cohort of patients with RA-ILD that started treatment with RTX due to ongoing progressive ILD despite treatment with glucocorticoids and csDMARDs or immunosuppressants (IS). All patients were treated with two or more cycles of RTX and evaluated for at least 12 months. Ongoing therapy with csDMARDs or IS remained unchanged. Results: Thirty-one patients were analyzed. Before initiation of RTX the mean decline (delta) in %pFVC and %pDLCO from the ILD diagnosis (median 21 months) was -16.5% and -19.7%, respectively. After 1 year of treatment, RTX was able to reverse the decline of pulmonary function test (PFTs) parameters: Delta%pFVC +8.06% compared to baseline (95% CI: -10.9 to -5.2; p |
| تدمد: | 0049-0172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4296b04d5a087bf5f6b1e3a3149ea715 https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8003 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..4296b04d5a087bf5f6b1e3a3149ea715 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00490172 |
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