First time in vivo assessment of sigma-1 receptor binding (Sig-1R) in the brain of unmedicated acute major depressive disorder (MDD) using the novel Sig-1R-specific radioligand (-)-[F-18]Fluspidine and PET
| العنوان: | First time in vivo assessment of sigma-1 receptor binding (Sig-1R) in the brain of unmedicated acute major depressive disorder (MDD) using the novel Sig-1R-specific radioligand (-)-[F-18]Fluspidine and PET |
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| المؤلفون: | Meyer, P. M., Strauß, M., Becker, G. A., Hesse, S., Bednasch, K., Ettrich, B., Zientek, F., Rullmann, M., Luthardt, J., Fischer, S., Patt, M., Wünsch, B., Brust, P., Sabri, O. |
| المصدر: | Nuklearmedizin 56(2018), V65 56. Jahrestagung der DGN, 18.-21.04.2018, Bremen, Deutschland |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | nervous system, mental disorders, behavioral disciplines and activities |
| الوصف: | Ziel/Aim: The Sig-1R is a chaperone protein localized at the endoplasmatic reticulum (ER) that can translocate under ER stress, a mechanism which is critically involved in the pathophysiology of MDD. In order to investigate the pathophysiology of Sig-1R regulation in MDD, for the first time we quantitatively assessed Sig-1R binding in the brain of unmedicated, acute MDD and compared it with healthy controls (HC) using the novel radioligand (-)-[F-18]Fluspidine and PET. Methodik/Methods: Unmedicated, moderate to severe, acute MDD (n=12; 33±13ys; 6 males: HAMD: 19.0±4.3; MDD+ with family histora [n=6] and MDD- without family history of depression [n=6]), were investigated using(-)-[F-18]Fluspidine PET (300 MBq, ECAT Exact HR+) and compared with age-/sex-matched healthy controls (HC; n=9; 37±16ys [n.s.]; 4 males [n.s]). Distribution volume parameters (VT) were determined using full pharmacokinetic modelling (2TCM, metabolite correction). Regional VOI-analyses were carried out. Ergebnisse/Results: Compared with HC, in MDD, VT was significantly higher within the ncl. caudatus, ncl. accumbens, fronto-temporo-parieto-occipital and cingulate cortices, insula, amygdala, thalamus and midbrain/raphe (+15 to +24%, PT was higher in the fronto -temporo and cingulate cortices, insula, hippocampus, putamen, thalamus (PT in the fronto-temporo-parietal and posterior cingulate cortices and thalamus (P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d7d1b4905ab11300e387165b9737516 https://www.hzdr.de/publications/Publ-27974-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.dedup.wf.001..3d7d1b4905ab11300e387165b9737516 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |