Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma
| العنوان: | Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma |
|---|---|
| المؤلفون: | Zhang, Guoliang, Liu, Xinyang, Wu, Jingjing, Zhu, Qikun, Zeng, Hui, Wang, Tao, Wang, Rui |
| المصدر: | DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname |
| بيانات النشر: | Universidad de Murcia. Departamento de Biología Celular e Histología, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Esophageal squamous cell carcinoma, ESCC, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], PTPRS, Immunohistochemistry, Tissue microarrays |
| الوصف: | Protein tyrosine phosphatase receptor type S is a tumor suppressor gene, located at chromosome 19p13.3, frequently inactivated through deletions or epigenetic mechanisms in many types of cancers. In this study, we investigate protein tyrosine phosphatase receptor S (PTPRS) expression level, clinicopathological and prognostic significance in 205 cases of esophageal squamous cell carcinoma (ESCC). Paraffin embedded tissue with immunohistochemistry methods was adopted to exam PTPRS expression in ESCC and paired normal esophageal mucosa tissues on Tissue Microarrays (TMAs). The protein tyrosine phosphatase receptor S was significantly down-regulated in ESCC (58.0%) relative to normal tissues (43.9%) (P=0.006). Statistical analysis revealed that reduced PTPRS expression was significantly associated with TNM stage (P=0.013), invasion depth (P |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9ecc1403a34b0a0e9948592cc41e559e http://hdl.handle.net/10201/120590 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.RECOLECTA.....9ecc1403a34b0a0e9948592cc41e559e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |