Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality
| العنوان: | Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality |
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| المؤلفون: | Lezoualc'h, F, Badimon, L, Baker, H, Bernard, M, Czibik, G, De Boer, RA, D'Humieres, T, Kergoat, M, Kowala, M, Rieusset, J, Vilahur, G, Detrait, M, Watson, C, Derumeaux, GA |
| المصدر: | CARDIOVASCULAR RESEARCH r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | OXFORD UNIV PRESS, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Heart Failure, Type 2 diabetes mellitus, Organ-to-organ interaction, Insulin resistance, Diabetic cardiomyopathy |
| الوصف: | Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery disease, and valvular or congenital heart disease, is now recognized as a distinct, multifactorial disease leading to ventricular hypertrophy and abnormal myocardial contractility that correlates with an array of complex molecular and cellular changes. Animal models provide the unique opportunity to investigate mechanistic aspects of diabetic CM, but important caveats exist when extrapolating findings obtained from preclinical models of diabetes to humans. Indeed, animal models do not recapitulate the complexity of environmental factors, most notably the duration of the exposure to insulin resistance that may play a crucial role in the development of diabetic CM. Moreover, most preclinical studies are performed in animals with uncontrolled or poorly controlled diabetes, whereas patients tend to undergo therapeutic intervention. Finally, whilst type 2 diabetes mellitus prevalence trajectory mainly increases at 40- < 75 years (with a currently alarming increase at younger ages, however), it is a legitimate concern how closely rodent models employing young animals recapitulate the disease developing in old people. The aim of this review is to identify the current limitations of rodent models and to discuss how future mechanistic and preclinical studies should integrate key confounding factors to better mimic the diabetic CM phenotype. |
| تدمد: | 0008-6363 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::7f01b04f7e179ebd35b3e1de121f57e9 https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13914 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.RECOLECTA.....7f01b04f7e179ebd35b3e1de121f57e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00086363 |
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