Environmental pollution is an emerging global issue, with severe impact on natural fields. The water contamination is the second most serious problem, right after the air pollution. 17α- Ethinylestradiol (EE2) is a synthetic steroid estrogen and commonly applied in controlling ovulation, as well as in treating alopecia, prostate and breast cancer in humans and reproductive disorders. Furthermore, it is also applied in contraceptives and in hormone replacement therapy. EE2 belongs to the group of endocrine disruptors and has been globally detected in surface water, sanitary sewage, drinking water and wastewater effluents from sewage treatment plants. Unfortunately, even at low concentrations EE2 can cause serious damages to the living organisms. Heterogeneous photocatalytic degradation is considered as competitive, effective, sustainable and green alternatives in the removal of persistent, non- biodegradable pollutants, since they can turn them into nontoxic CO2 and H2O. In this study, the efficiency of photocatalytic degradation of EE2 in the presence of undoped and doped (Eu, Tb, Ho) LaMnO3 nanomaterials (synthesized by sol-gel technique) was investigated under UV light and simulated sunlight irradiation. The best removal efficiency was reached in the presence of LMO:Ho, when 77% of endocrine disruptors EE2 was degraded after 30 min of UV irradiation.