Hydrazone derivatives of vitamin B6, pyridine-4- carbaldehyde and 2-quinolinecarbaldehyde (1-15) were synthesized. Phenyl-hydrazine and substituted phenyl-hydrazines were used for the synthesis: 2, 4-dinitrophenyl-hydrazine, 4- chlorophenyl- hydrazine, 4-fluorophenylhydrazine, 4- methylphenyl-hydrazine. The reactions were performed in two different solvents, acetone and ethanol, to examine the effect of solvent polarity and absorption power on the reaction yield. The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. The syntheses were carried out under the influence of microwave radiation, a more environmentally friendly method by which the desired product can be obtained in a much shorter time. The research investigates how microwave radiation, as one of the alternative synthesis methods, and the choice of solvent affect the chemical yields compared to conventional synthesis methods of hydrazone derivatives. The obtained results were compared with the research results of other authors who obtained similar or same hydrazones by classical organic synthesis. [1-3]