Periodical
Calculating Apparent pKaValues of Ionizable Lipids in Lipid Nanoparticles
| العنوان: | Calculating Apparent pKaValues of Ionizable Lipids in Lipid Nanoparticles |
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| المؤلفون: | Hamilton, Nicholas B., Arns, Steve, Shelley, Mee, Bechis, Irene, Shelley, John C. |
| المصدر: | Molecular Pharmaceutics; January 2025, Vol. 22 Issue: 1 p588-593, 6p |
| مستخلص: | Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent pKavalue of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for the prediction of the apparent pKavalue of ionizable lipids within LNPs and have tested it using the lipid formulations in the mRNA LNP COVID-19 vaccines COMIRNATY and Spikevax, and the siRNA LNP therapeutic Onpattro. The calculation was also applied to Lipid A, a variant of the ionizable lipid used in COMIRNATY. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 15438384 15438392 |
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| DOI: | 10.1021/acs.molpharmaceut.4c00426 |