Periodical
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer
| العنوان: | Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer |
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| المؤلفون: | Zhu, Norman, Rogers, W. Eric, Heidary, David K., Huxford, Tom |
| المصدر: | Genes & Development; 2024, Vol. 38 p528-535, 8p |
| مستخلص: | In this study, Zhu et al. describe the structure of the IκBζ in complex with NF-κB's p50 homodimer and dissect the domain functions involved in their folding stability and binding affinity and specificity. They also show that IκBζ interacts with p50:RelA heterodimers, not only providing insight into the structural rearrangements that are required for the complex's association with target DNA but also suggesting that IκBζ serves as a transcriptional coregulator for both RelA- and NFκB-dependent gene expression. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 08909369 15495477 |
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| DOI: | 10.1101/gad.351892.124 |