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Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy.
| العنوان: | Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy. |
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| المؤلفون: | Leung, Joseph C K, Tang, Sydney C W, Chan, Loretta Y Y, Tsang, Anita W L, Lan, Hui Yao, Lai, Kar Neng |
| المصدر: | Nephrology Dialysis Transplantation; January 2003, Vol. 18 Issue: 1 p36-45, 10p |
| مستخلص: | It has been suggested that polymeric IgA (pIgA) or IgA immune complexes play a significant pathogenic role in IgA nephropathy (IgAN). Macrophage migration inhibitory factor (MIF) shares many activities with other pro-inflammatory cytokines. In human glomerulonephritis, including IgAN, glomerular expression of MIF is found to correlate with progressive renal injury. We hypothesized that deposition of pIgA within the kidney may lead to enhanced synthesis of MIF by mesangial cells. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 09310509 14602385 |
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| DOI: | 10.1093/ndt/18.1.36 |