Periodical
Antioxidant, Antibacterial, and Antiparasitary Activities of Green Nanoparticles Synthesized Using Water-Soluble Melanins of Fruits
| العنوان: | Antioxidant, Antibacterial, and Antiparasitary Activities of Green Nanoparticles Synthesized Using Water-Soluble Melanins of Fruits |
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| المؤلفون: | Montes-Avila, Julio, López-Angulo, Gabriela, Duarte-de-la-Peña, Gisela, Díaz-Camacho, Sylvia Páz, Osuna-Galindo, Velia Carolina, López-Valenzuela, José Ángel, Delgado-Vargas, Francisco |
| المصدر: | BioNanoScience; March 2022, Vol. 12 Issue: 1 p228-240, 13p |
| مستخلص: | Up to date, fruit melanins have not been employed to synthesize nanoparticles (NPs). Crescentia alata, Randia echinocarpa, and Vitex mollisfruit are used in traditional medicine, and their soluble melanins (SMes) have high antioxidant activity. These SMes were used to prepare silver (green-AgNPs) and gold (green-AuNPs) NPs and evaluate their antioxidant capacity (DPPH and FRAP), activity against human pathogens (bacteria and the parasite Hymenolepis nana), and toxicity (Artemia salinaassay). All SMes were useful to synthesize green-AgNPs but only V. mollisSMe for green-AuNPs. Infrared spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM) showed that SMe is on the green-NPs surface. TEM showed 13–31-nm spherical green-AgNPs and 2–16-nm spherical and cylindrical green-AuNPs. Green-AgNPs showed higher antioxidant (FRAP = 3.4–725.4 µmol TE g−1; DPPH = 10.9–748.2 µmol TE g−1) and antibacterial (MIC = 1.85–15 µg mL−1; MBC = 3.7–30 µg mL−1) activities than the chemical-NPs. Moreover, the green-NPs (25 mg mL−1) were active against H. nanawith the following times (min) (paralysis, death): green-AgNPs (10–40, 15–90) and V. mollisAuNPs (28, 40). The toxicity of the green-NPs (LC50= 61.6 to > 1000 μg mL−1) depended on the SMe employed in the preparation. V. mollisNPs were the less toxic: minimal toxicity for the AgNPs (LC50= 826.91 μg mL−1) and non-toxic for the AuNPs (LC50> 1000 µg mL−1). Thus, the SMes are useful to obtain green-NPs of high stability that showed activities against human pathogens, suggesting their potential to be used as alternative health treatments. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 21911630 21911649 |
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| DOI: | 10.1007/s12668-022-00940-y |