Brucella– Virulence Factors, Pathogenesis and Treatment

التفاصيل البيبلوغرافية
العنوان:	Brucella– Virulence Factors, Pathogenesis and Treatment
المؤلفون:	GŁOWACKA, PATRYCJA, ŻAKOWSKA, DOROTA, NAYLOR, KATARZYNA, NIEMCEWICZ, MARCIN, BIELAWSKA-DRÓZD, AGATA
المصدر:	Polish Journal of Microbiology; June 2018, Vol. 67 Issue: 2 p151-161, 11p
مستخلص:	Brucellaeare Gram-negative, small rods infecting mammals and capable of causing disease called brucellosis. The infection results in abortion and sterility in domestic animals (sheeps, pigs, rams etc). Especially dangerous for humans are: Brucella melitensis, Brucella suis, Brucella abortus, and Brucella canisthat trigger unspecific symptoms (flu-like manifestation). Brucellarods are introduced via host cells, by inhalation, skin abrasions, ingestion or mucosal membranes. The most important feature of Brucellais the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucelladoes not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (BrucellaContaining Vacuole) and interaction with endoplasmic reticulum (ER) when the bacteria multiply. The treatment of brucellosis is based on two-drug therapy, the most common combinations of antibiotics are: doxycycline with rifampicin or fluoroquinolones with rifampicin. Currently, also other methods are used to disrupt Brucellaintracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
قاعدة البيانات:	Supplemental Index

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تدمد:	17331331 25444646
DOI:	10.21307/pjm-2018-029