Periodical
A Portable System for Processing Donated Whole Blood into High Quality Components without Centrifugation
| العنوان: | A Portable System for Processing Donated Whole Blood into High Quality Components without Centrifugation |
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| المؤلفون: | Gifford, Sean C., Strachan, Briony C., Xia, Hui, Vörös, Eszter, Torabian, Kian, Tomasino, Taylor A., Griffin, Gary D., Lichtiger, Benjamin, Aung, Fleur M., Shevkoplyas, Sergey S. |
| المصدر: | Blood; December 2017, Vol. 130 Issue: 1, Number 1 Supplement 1 p2401-2401, 1p |
| مستخلص: | Introduction: Centrifugation is the cornerstone of blood processing because it has been the only technology capable of separating large volumes of whole blood (WB) into components for storage under optimal conditions in a reasonable amount of time. However, the logistical complications and potential cellular damage associated with centrifugation-based manufacturing of blood products are well documented. In this study, we present a new dual-stage, passive separation system for processing WB into components, which does not require costly or complex machinery, and can be used on-site by minimally-trained personnel immediately following blood donation. This approach consists of two passive blood-processing modules, neither of which requires electricity: (i) a blood-bag compression apparatus designed to maximize the speed and efficiency of passive RBC sedimentation for separating RBCs and platelet-rich plasma (PRP) from WB at normal gravity (i.e. 1×g), and (ii) a flow-through microfluidic concentrator for continuous high-throughput enrichment of platelets from the PRP fraction, to produce platelet concentrate (PC) and platelet-poor plasma (PPP). The ability of this technology to produce high-quality blood components quickly without the use of a centrifuge was demonstrated. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V130.Suppl_1.2401.2401 |