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PD-L1Gene Alterations Identify a Unique Subset of Diffuse Large B Cell Lymphoma That Harbors a T Cell Inflamed Phenotype
| العنوان: | PD-L1Gene Alterations Identify a Unique Subset of Diffuse Large B Cell Lymphoma That Harbors a T Cell Inflamed Phenotype |
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| المؤلفون: | Kline, Justin, Godfrey, James, Tumuluru, Sravya, Venkataraman, Girish, Orlowski, Robert J, Smith, Sonali M., Bao, Riyue |
| المصدر: | Blood; November 2018, Vol. 132 Issue: 1, Number 1 Supplement 1 p673-673, 1p |
| مستخلص: | Background:Programmed death - ligand 1 (PD-L1) expression is a dominant immune escape mechanism across human cancers. Ubiquitous copy gains of chromosome 9p24.1 - a region containing the PD-L1and PD-L2loci - lead to PD-L1 expression on Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma. PD-L1gene alterations also occur in diffuse large B cell lymphoma (DLBCL), albeit less commonly. Hypothesizing that PD-L1gene alterations identify DLBCLs in which potent anti-lymphoma immune responses have been activated, we aimed to characterize the immune landscape of PD-L1gene-altered DLBCLs, describe the key clinical features of these patients, and determine the degree to which PD-L1gene alterations predict for response to PD-1 blockade therapy in DLBCL. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood-2018-99-117189 |