Periodical
Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis
| العنوان: | Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis |
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| المؤلفون: | Sarink, Maarten J., Tielens, Aloysius G. M., Verbon, Annelies, Sutak, Robert, van Hellemond, Jaap J. |
| المصدر: | Antimicrobial Agents and Chemotherapy; May 2020, Vol. 64 Issue: 8 |
| مستخلص: | Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri. The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close relative of N. fowleri, prefers lipids over glucose as an energy source. Therefore, we tested several already-approved inhibitors of fatty acid oxidation alongside the currently used drugs amphotericin B and miltefosine. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00664804 10986596 |
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| DOI: | 10.1128/AAC.00344-20 |