Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome

التفاصيل البيبلوغرافية
العنوان:	Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome
المؤلفون:	Hayashi, Y, Eguchi, M, Sugita, K, Nakazawa, S, Sato, T, Kojima, S, Bessho, F, Konishi, S, Inaba, T, Hanada, R
المصدر:	Blood; July 1988, Vol. 72 Issue: 1 p15-23, 9p
مستخلص:	Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, platelet counts, and WBC counts of DS-TMD patients provided a clinical contrast with the frankly leukemic cases. Myelodysplastic syndrome, characterized by a small percentage of leukemic blast cells, was observed in 11 of the 13 patients with DS-AL compared with none in the DS-TMD group. Electron microscopy disclosed a positive platelet peroxidase reaction in each of the 11 DS-TMD patients and in nine of the 13 DS-AL patients. Immunologic studies revealed antiplatelet- megakaryocyte antigens on the blast cells of the majority of patients in both study groups. Our findings suggest that the blast cells in cases of DS-AL and DS-TMD arise from cells of the megakaryocytic lineage or from a myeloid progenitor with the capacity for megakaryocytic differentiation. The high risk of the development of AL in patients with DS who are less than 3 years old may be related to increased megakaryocyte proliferation in this age group.
قاعدة البيانات:	Supplemental Index

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تدمد:	00064971 15280020
DOI:	10.1182/blood.V72.1.15.15