Periodical
A short-term study of the additive effect of latanoprost 0.005% and brimonidine 0.2%
| العنوان: | A short-term study of the additive effect of latanoprost 0.005% and brimonidine 0.2% |
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| المؤلفون: | Erdogˇan, Haydar, Toker, I˙lker, Arıcı, Mustafa Kemal, Aygen, Ahmet, Topalkara, Ays¸en |
| المصدر: | Japanese Journal of Ophthalmology; 2003, Vol. 47 Issue: 5 p473-478, 6p |
| مستخلص: | Purpose: To evaluate the short-term additive effects of latanoprost 0.005% and brimonidine 0.2%. Methods: This study was a randomized, double-masked, cross-over study that included 32 patients (32 eyes) with primary open-angle glaucoma or exfoliation glaucoma. On baseline day, intraocular pressure (IOP) was measured at 10 am and 11 pm . Baseline IOP values were obtained by calculating the mean values for both eyes. After this process, latanoprost 0.005% was prescribed once a day during the first 5 days at 10 pm as the first test drug. During the second 5 days, twice a day brimonidine 0.2% or a placebo, as the second test drug, was added to the latanoprost at 9 am and 10 pm . After a 4-week washout period, latanoprost 0.005% was prescribed once a day during the first 5 days at 10 pm and during the second 5 days, the second test drug, brimonidine or a placebo, was added to latanoprost, and the two drugs were prescribed twice a day for 5 days. Results: During the second 5 days, although an additional 2.53-3.10 mm Hg decrease in IOP was determined in the latanoprost + brimonidine group, there was no additional decrease in the latanoprost + placebo group. Conclusions: This study showed that brimonidine and latanoprost have an additive IOP-lowering effect in open-angle glaucoma patients in the short term. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00215155 16132246 |
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| DOI: | 10.1016/S0021-5155(03)00106-0 |